As far as networking goes, you should really know the following applications: Microsoft Exchange Server; the Novell group wise; client server; and sequel database applications. Your sweet spot clients will most likely need you to service these systems.
In the accounting world, you should have experience and/or training with Microsoft business solutions and Great Plains’ Best 90. CRM applications you'll need include Best Software and Microsoft Business Solutions products. Web servers, administering Microsoft IS and the Open Source Apache will all be important areas of your business.
Learn more about what you need to know for sweet spot customers in the complete article (link above).
Blogged by Computer Consulting 101 Professional Kit